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Pharmacokinetic data; Bioavailability >80%: Metabolism: Hydrocodone: extensively liver, primarily CYP3A4; /Paracetamol: liver, CYP2E1 Elimination half-life: for hydrocodone: 228–294 mins (3.8–4.9 hrs); for paracetamol: 120–240 mins (2–4 hrs)
Codeine/paracetamol, also called codeine/acetaminophen and co-codamol, is a compound analgesic, comprising codeine phosphate and paracetamol (acetaminophen). Codeine/paracetamol is used for the relief of mild to moderate pain when paracetamol or non-steroidal anti-inflammatory drugs (NSAIDs; such as ibuprofen, aspirin, and naproxen) alone do not sufficiently relieve symptoms.
Therefore, one could extract all 256mg of Codeine Phosphate in a standard 8/500mg Co-codamol pack of 32 in a comparatively tiny amount of liquid. Even if the user starts the CWE process with 50ml water, (which, theoretically could hold 200g codeine phosphate), the maximum amount of paracetamol consumed will be 450mg (50ml*9mg/ml=450mg), which ...
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Co-codamol is only a British name, in the rest of the world this is kown by its full names of Paracetamol and Codeine. Should brandnames for non British products (eg Panadeine, from Australia) direct here? It would make more sense for a page detailing the common analgesic combo paracetamol with codeine, and have co-codamol redirect there
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Cold water extraction (also called CWE) is the process whereby a substance is extracted from a mixture via cold water. It is a type of fractional crystallization . The process generally involves taking a mixture of substances, dissolving them in warm water, and then rapidly cooling the mixture.
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