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Inflammation is a general marker of tissue damage in any disease, and may be either secondary to tissue damage in Alzheimer's disease or a marker of an immunological response. [117] There is increasing evidence of a strong interaction between the neurons and the immunological mechanisms in the brain.
Posterior cortical atrophy (PCA), also called Benson's syndrome, is a rare form of dementia which is considered a visual variant or an atypical variant of Alzheimer's disease (AD). [ 1 ] [ 2 ] [ 3 ] The disease causes atrophy of the posterior part of the cerebral cortex , resulting in the progressive disruption of complex visual processing . [ 4 ]
Alzeimer's (Alzheimer) disease is a neurodegenerative disease that leads to symptoms of dementia. Progression of Alzheimer's disease is thought to involve an accumulation of beta-amyloid plaque and neurofibrillary tangles in the brain. This video covers the mechanisms and pathophysiology thought to contribute to Alzheimer's disease, including a ...
The diagnosis of Alzheimer's disease typically requires a microscopic analysis of plaques and tangles in brain tissue, usually at autopsy. [40] However, Aβ plaques (along with cerebral Aβ-amyloid angiopathy ) can be detected in the brains of living subjects by preparing radiolabeled agents that bind selectively to Aβ deposits in the brain ...
CAA is associated with brain hemorrhages, particularly microhemorrhages.The accumulation of amyloid beta peptide deposits in the blood vessel walls results in damage of the blood vessels and hindrance of normal blood flow, making blood vessels more prone to bleeding [10] Since CAA can be caused by the same amyloid protein that is associated with Alzheimer's dementia, brain bleeds [11] are more ...
Frontotemporal dementia (FTD), also called frontotemporal degeneration disease [1] or frontotemporal neurocognitive disorder, [2] encompasses several types of dementia involving the progressive degeneration of the brain's frontal and temporal lobes. [3] Men and women appear to be equally affected. [1]
[70] [68] Increased oxidative DNA damage in the brain is associated with Alzheimer's disease and Parkinson's disease. [70] Defective DNA repair has been linked to neurodegenerative disorders such as Alzheimer's disease, amyotrophic lateral sclerosis, ataxia telangiectasia, Cockayne syndrome, Parkinson's disease and xeroderma pigmentosum. [70] [69]
Alzheimer's disease (AD) is a progressive, degenerative and fatal brain disease, in which cell to cell connections in the brain are lost. Alzheimer's disease is the most common form of dementia. [2] Globally approximately 1–5% of the population is affected by Alzheimer's disease. [3] Women are disproportionately affected by Alzheimer's disease.
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