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Cryptococcus (Cryptococcal meningitis) - it is thought to be acquired through inhalation of soil contaminated with bird droppings. C. neoformans is the most common pathogen to cause fungal meningitis. Aspergillus - Aspergillus infections account for 5% of fungal infections involving the central nervous system.
Fungal meningitis, such as cryptococcal meningitis, is treated with long courses of high dose antifungals, such as amphotericin B and flucytosine. [ 55 ] [ 82 ] Raised intracranial pressure is common in fungal meningitis, and frequent (ideally daily) lumbar punctures to relieve the pressure are recommended, [ 55 ] or alternatively a lumbar drain.
They include mostly viral infections, less commonly bacterial infections, fungal infections, prion diseases and protozoan infections. Neonatal meningitis is a particular classification by age. By anatomical site
Aspergillus fumigatus is the most frequent cause of invasive fungal infection in immunosuppressed individuals, which include patients receiving immunosuppressive therapy for autoimmune or neoplastic disease, organ transplant recipients, and AIDS patients. [11]
Infection begins in the lungs, and from there the fungus can disseminate to the brain and other body parts via macrophages. An infection of the brain caused by C. neoformans is referred to as cryptococcal meningitis, which is most often fatal when left untreated. [5] [29] Cryptococcal meningitis causes more than 180,000 deaths annually. [30]
Cryptococcosis is a potentially fatal fungal infection of mainly the lungs, presenting as a pneumonia, and in the brain, where it appears as a meningitis. [4] [9] Coughing, difficulty breathing, chest pain and fever are seen when the lungs are infected. [5]
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Fungal infections from Aspergillus spores remain one theory of sickness and untimely death of some early Egyptologists and tomb explorers. Ancient spores which grew on the remains of food offerings and mummies sealed in tombs and chambers may have been blown around and inhaled by the excavators, ultimately linked to the notion of the curse of ...