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Cartoon representation of the protein Zif268 (blue) containing three zinc fingers in complex with DNA (orange). The coordinating amino acid residues and zinc ions (green) are highlighted. A zinc finger is a small protein structural motif that is characterized by the coordination of one or more zinc ions (Zn 2+) which stabilizes the
It is also known as Smad-interacting zinc finger protein 2 (SIZN2), para-neoplastic Ma antigen family member 7b (PNMA7B), and LOC644353. [4] [5] Other names such as zinc finger, CCHC domain containing 12 pseudogene 1, P0CG32, ZCC18_HUMAN had been used to describe this protein. ZCCHC18 belongs to the ZCCHC12 family or para-neoplastic Ma (PNMA).
The protein encoded by this gene belongs to the C2H2-type zinc-finger protein family. The exact function of this gene is not known, however, zinc-finger proteins are known to interact with DNA and function as transcription regulators. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
The encoded protein has five LIM domains, each domain forming two zinc fingers, which permit interactions which regulate cell shape and migration. A pseudogene of this gene is located on chromosome 4. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011].
227449 Ensembl ENSG00000141664 ENSMUSG00000038866 UniProt Q9C0B9 Q69ZB8 RefSeq (mRNA) NM_017742 NM_001122675 NM_001122676 RefSeq (protein) NP_060212 NP_001116147 NP_001116148 Location (UCSC) Chr 18: 62.52 – 62.59 Mb Chr 1: 105.92 – 105.96 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Zinc finger CCHC domain-containing protein 2 is a protein that in humans is encoded by the ...
52915 Ensembl ENSG00000122515 ENSMUSG00000041164 UniProt Q8NF64 Q8CIE2 RefSeq (mRNA) NM_001300959 NM_031449 NM_174929 NM_001005867 NM_028601 RefSeq (protein) NP_001287888 NP_113637 NP_777589 NP_001005867 NP_082877 Location (UCSC) Chr 7: 44.75 – 44.77 Mb Chr 11: 6.39 – 6.41 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Zinc finger MIZ domain-containing protein 2 is a protein ...
53861 Ensembl ENSG00000132485 ENSMUSG00000028180 UniProt O95218 Q9R020 RefSeq (mRNA) NM_005455 NM_203350 NM_017381 NM_001355381 NM_001355386 RefSeq (protein) NP_005446 NP_976225 NP_059077 NP_001342310 NP_001342315 Location (UCSC) Chr 1: 71.06 – 71.08 Mb Chr 3: 157.24 – 157.25 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Zinc finger Ran-binding domain-containing protein 2 is a ...
The zinc finger-containing protein encoded by this gene is a widely expressed member of the FOG family of regulators of transcription factors. The family consists of the ZFPM1 and ZFPM2 genes in humans and Zfpm1 and Zfpm2 genes in mice. Its members may act as coactivators and/or corepressors to modulate the activity of GATA transcription factors.