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In men, lower-limb primary lymphedema is most common, occurring in one or both legs. Some cases of lymphedema may be associated with other vascular abnormalities. [4] [citation needed] Secondary lymphedema affects both men and women, and, in Western countries, is most commonly due to cancer treatment. [14]
The pathophysiology is not yet well understood. Leukocytoclastic vasculitis is proposed to be the underlying cause resulting in reactive lymphedema. [2] Prolonged standing with full knee extension and minimal movement for a prolonged period of time is postulated to induce a temporary failure in pumping the venous and lymphatic systems in the calf region leading to acute gravity-dependent ...
Lipedema is a condition that is almost exclusively found in women [3] and results in enlargement of both legs due to deposits of fat under the skin. [2] Women of any weight may be affected [2] [3] and the fat is resistant to traditional weight-loss methods. [4]
Pain or fatigue in the legs while walking ... and ankles—often called peripheral edema—can be a telltale sign of congestive heart failure. ... For both men and women, the most common heart ...
Milroy's disease is also known as primary or hereditary lymphedema type 1A or early onset lymphedema. It is a very rare disease with only about 200 cases reported in the medical literature. Milroy's disease is an autosomal dominant condition caused by a mutation in the FLT4 gene which encodes the vascular endothelial growth factor receptor 3 ...
Signs and symptoms of CVI in the leg include the following: Varicose veins; Itching ; Hyperpigmentation; Phlebetic lymphedema [7] Chronic swelling of the legs and ankles; Leg ulcer; CVI in the leg may cause the following: Venous stasis; Venous ulcers [8] Stasis dermatitis, [8] also known as varicose eczema
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