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Hepatocyte growth factor receptor (HGF receptor) [5] [6] is a protein that in humans is encoded by the MET gene.The protein possesses tyrosine kinase activity. [7] The primary single chain precursor protein is post-translationally cleaved to produce the alpha and beta subunits, which are disulfide linked to form the mature receptor.
Hepatocyte growth factor has been shown to interact with the protein product of the c-Met oncogene, identified as the HGF receptor . [6] [34] [35] Both overexpression of the Met/HGFR receptor protein and autocrine activation of Met/HGFR by simultaneous expression of the hepatocyte growth factor ligand have been implicated in oncogenesis.
Receptor tyrosine kinases (RTKs) are a vital element in regulating many intracellular signal transduction pathways. [13] Met tyrosine kinase is the receptor for hepatocyte growth factor (HGF), also known as scatter factor (SF). HGF is mostly expressed on epithelial cells and mesenchymal cells, for example smooth muscle cells and fibroblasts.
He used hepatocyte cultures as bioassays and discovered and identified HGF as a circulating mitogen in peripheral blood. [10] He also found that HGF functions as the ligand for the c-MET receptor, with HGF stimulating phosphorylation and kinase activity of the p190c-met protein, documenting the functional interaction between the two. [11]
3480 16001 Ensembl ENSG00000140443 ENSMUSG00000005533 UniProt P08069 Q60751 RefSeq (mRNA) NM_000875 NM_001291858 NM_152452 NM_010513 RefSeq (protein) NP_000866 NP_001278787 NP_034643 Location (UCSC) Chr 15: 98.65 – 98.96 Mb Chr 7: 67.6 – 67.88 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse The insulin-like growth factor 1 (IGF-1) receptor is a protein found on the surface of ...
MACC1 is a key regulator of the hepatocyte growth factor (HGF)-HGF receptor (HGFR) pathway, which is involved in cellular growth, epithelial-mesenchymal transition, angiogenesis, cell motility, invasiveness, and metastasis.
“This study highlights BCL6 as a potential therapeutic target for muscle loss due to aging, cancer cachexia, obesity and complications from its treatment (e.g., GLP-1 receptor agonists), which ...
The epidermal growth factor receptor is a member of the ErbB family of receptors, a subfamily of four closely related receptor tyrosine kinases: EGFR (ErbB-1), HER2/neu (ErbB-2), Her 3 (ErbB-3) and Her 4 (ErbB-4). In many cancer types, mutations affecting EGFR expression or activity could result in cancer. [6]