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Lameness is most commonly associated with injury to synovial joints, or those joints containing articular cartilage, a joint capsule, and a synovial membrane.Joint disease may affect the joint capsule and synovial membrane, articular cartilage, subchondral bone (the bone underneath the cartilage), menisci, or any ligaments associated with the joint.
This liquid supplement is a daily, oral version of hyaluronic acid (HA), also called sodium hyaluronate, which had normally been administered by injection. HA is used to promote normal joint function, and to improve joint comfort and performance. LubriSyn is available for horses, humans, and pets. [1]
Side effects from intra-articular administration can include joint pain, swelling, lameness, and, rarely, infection of the joint. Intramuscular injection can cause dose-dependent inflammation and bleeding, since PSGAG is an analogue of the anticoagulant heparin. [4] In dogs, this may manifest as bleeding from the nose or as bloody stools. [7]
Equine studies have shown that grapiprant is present in urine 96 hours after the first administration of a dose of 2 mg/kg and has a concentration >0.005 ng/ml. From the excreted dose conducted in horses, it is found that 55%, 15% and 19% of the orally-administered dose was excreted in bile, urine, and faeces respectively.
Hyaluronan is used in treatment of articular disorders in horses, in particular those in competition or heavy work. [67] It is indicated for carpal and fetlock joint dysfunctions, but not when joint sepsis or fracture are suspected. It is especially used for synovitis associated with equine osteoarthritis. It can be injected directly into an ...
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