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Schematic of the relation between an immunoglobulin and RAGE Schematic of the RAGE gene and its products. RAGE (receptor for advanced glycation endproducts), also called AGER, is a 35 kilodalton transmembrane receptor [5] of the immunoglobulin super family which was first characterized in 1992 by Neeper et al. [6] Its name comes from its ability to bind advanced glycation endproducts (), which ...
AGEs have specific cellular receptors; the best-characterized are those called RAGE. The activation of cellular RAGE on endothelium, mononuclear phagocytes, and lymphocytes triggers the generation of free radicals and the expression of inflammatory gene mediators. [ 28 ]
5891 26448 Ensembl ENSG00000080823 ENSMUSG00000056458 UniProt Q9UQ07 Q9WVS4 RefSeq (mRNA) NM_001272011 NM_014226 NM_001330234 NM_001353827 NM_001353828 NM_001353829 NM_001353830 NM_001353831 NM_001353832 NM_011973 RefSeq (protein) NP_001258940 NP_001317163 NP_055041 NP_001340756 NP_001340757 NP_001340758 NP_001340759 NP_001340760 NP_001340761 NP_036103 Location (UCSC) Chr 14: 102.22 – 102.31 ...
Once a DAMP is released from the cell, it promotes a noninfectious inflammatory response by binding to a pattern recognition receptor (PRR). [4] Inflammation is a key aspect of the innate immune response; it is used to help mitigate future damage to the organism by removing harmful invaders from the affected area and start the healing process ...
HMGB1 has to interact with p53. [15] [16]HMGB1 is a nuclear protein that binds to DNA and acts as an architectural chromatin-binding factor. It can also be released from cells, an extracellular form in which it may bind to toll-like receptors (TLRs) or an inflammatory receptor called the receptor for advanced glycation end-products RAGE.
De la Rocha was born in Long Beach, California, on January 12, 1970, to Robert "Beto" de la Rocha and Olivia Lorryne Carter. [5] His father is a Mexican-American, [6] with distant African and Sephardi Jewish heritage, [7] [8] while his mother was born to Manuel García Urias, a Mexican-American, and Olive Pearl Fleming, who was of German and Irish heritage.
Robin Yvette Allen (born February 6, [1] 1968), known professionally as The Lady of Rage, is an American rapper, singer and actress best known for her collaborations with several other Death Row Records artists, including Dr. Dre and Snoop Dogg on the seminal albums, The Chronic and Doggystyle. [3]
Dale Anthony Resteghini (born August 28, 1968), known professionally as Rage, is an American music video director and film director. He has been credited on music videos for prominent music industry acts in the genres of hardcore , heavy metal , rock , punk , hip hop and gangsta rap .