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Here they form large complexes, both to other proteoglycans, to hyaluronan, and to fibrous matrix proteins, such as collagen. The combination of proteoglycans and collagen form cartilage , a sturdy tissue that is usually heavily hydrated (mostly due to the negatively charged sulfates in the glycosaminoglycan chains of the proteoglycans). [ 5 ]
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Collagen XVII is a homotrimer of three alpha1(XVII)-chains [11] and a transmembrane protein in type II orientation. Each 180 kD a-chain contains a globular intracellular domain of approximately 70 kDa, which interacts with beta4-integrin, plectin, and BP230 [12] [13] and is necessary for the stable attachment of hemidesmosomes to keratin intermediate filaments.
3673 16398 Ensembl ENSG00000164171 ENSMUSG00000015533 UniProt P17301 Q62469 RefSeq (mRNA) NM_002203 NM_008396 RefSeq (protein) NP_002194 NP_032422 Location (UCSC) Chr 5: 52.99 – 53.09 Mb Chr 13: 114.97 – 115.07 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Integrin alpha-2, or CD49b (cluster of differentiation 49b), is a protein which in humans is encoded by the CD49b gene. The ...
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Collagens are complex molecules that provide structure, strength, and elasticity to connective tissue. Type II and type XI collagen disorders are grouped together because both types of collagen are components of the cartilage found in joints and the spinal column, the inner ear, and the jelly-like substance that fills the eyeball (the vitreous ...
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