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The vnd/NK-2 homeodomain-DNA complex. Helix 3 of the homeodomain binds in the major groove of the DNA and the N-terminal arm binds in the minor groove, in analogy with other homeodomain-DNA complexes. Helix 2 and helix 3 form a so-called helix-turn-helix (HTH) structure, where the two alpha helices are connected by a short loop region.
Figure 1. TATA box structural elements. The TATA box consensus sequence is TATAWAW, where W is either A or T. In molecular biology, the TATA box (also called the Goldberg–Hogness box) [1] is a sequence of DNA found in the core promoter region of genes in archaea and eukaryotes. [2]
There were nine common sequences found to be conserved amongst the studied species, which is an important criterion of the DEAD box family. [5] The nine conserved motif from the N-terminal to the C-terminal are named as follows: Q-motif, motif 1, motif 1a, motif 1b, motif II, motif III, motif IV, motif V, and motif VI, as shown in the figure.
Terminal transferase has applications in molecular biology. It can be used in RACE to add nucleotides that can then be used as a template for a primer in subsequent PCR . It can also be used to add nucleotides labeled with radioactive isotopes , for example in the TUNEL assay ( T erminal deoxynucleotidyl transferase d U TP N ick E nd L abeling ...
The terminal web is a filamentous structure found at the apical surface of epithelial cells that possess microvilli. It is composed primarily of actin filaments stabilized by spectrin, which also anchors the terminal web to the apical cell membrane. The presence of myosin II and tropomyosin helps to explain the contractile ability of the ...
The terminal investment hypothesis is the idea in life history theory that as an organism's residual reproductive value (or the total reproductive value minus the reproductive value of the current breeding attempt) decreases, its reproductive effort will increase. Thus, as an organism's prospects for survival decreases (through age or an immune ...
SOX genes (SRY-related HMG-box genes) encode a family of transcription factors that bind to the minor groove in DNA, and belong to a super-family of genes characterized by a homologous sequence called the HMG-box (for high mobility group). This HMG box is a DNA binding domain that is highly conserved throughout eukaryotic species.
The MADS box is a conserved sequence motif. The genes which contain this motif are called the MADS-box gene family. [1] The MADS box encodes the DNA-binding MADS domain. The MADS domain binds to DNA sequences of high similarity to the motif CC[A/T] 6 GG termed the CArG-box. [2] MADS-domain proteins are generally transcription factors.