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Being the main chemical that causes heat in chili pepper, the main side effect of capsaicin is a burning sensation that usually persists for several days. A topical anaesthetic can be used to reduce the sensation. In addition, the topical anaesthetic can also provide anti-itch effect on its own. [55]
Dysesthesia is commonly seen in diabetic patients, and can be relieved by using creams containing capsaicin. Dysesthesia may be seen in patients with Guillain–Barré syndrome. Dysesthesia is among symptoms of neuropathy (along with paresthesias, gait disturbance, weakness, and absent DTRs).
In high concentrations, capsaicin will also cause a burning effect on other sensitive areas, such as skin or eyes. [15] The degree of heat found within a food is often measured on the Scoville scale. [14] There has long been a demand for capsaicin-spiced products like chili pepper, and hot sauces such as Tabasco sauce and Mexican salsa. [14]
High concentration topical capsaicin (8%, Qutenza) have been shown to be highly effective in treating neuropathic itch in some patients [12] [13] (including notalgia paresthetica) as well as in a recent proof-of-concept study. [14] Most recently intradermal injections of botulinum toxin type A (Botox) have been tried with some success. Even ...
Bengay and similar products, such as Flexall, Mentholatum, Capzasin and Icy Hot, variously contain menthol, methyl salicylate (oil of wintergreen), and capsaicin as active ingredients and have a potential to cause first-to-third-degree chemical burns. [4] [5] Some people have been hospitalized after receiving such burns. [4]
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Itching is one of the most frequent adverse effects of opioid therapy. [4] A common artificial colloid used in clinical fluid management is hydroxyethyl starch (HES). Well-defined side effects, such as coagulopathy, clinical bleeding, anaphylactoid reactions, and pruritus, can make using HES more difficult. [5]
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