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Water retention, ionic changes, and acidification of the cell damages membrane-bound intracellular structures including the lysosome and peroxisome. [ 1 ] Lysosomes are membrane-bound organelles that typically contain a broad spectrum of enzymes capable of hydrolytic deconstruction of polysaccharides , proteins , nucleic acids , lipids ...
The mucopolysaccharidoses are part of the lysosomal storage disease family, a group of genetic disorders that result when the lysosome organelle in animal cells malfunctions. The lysosome can be thought of as the cell's recycling center because it processes unwanted material into other substances that the cell can utilize. Lysosomes break down ...
Similarly, they are able to break down virus particles or bacteria in phagocytosis of macrophages. The size of lysosomes varies from 0.1 μm to 1.2 μm. [24] With a pH ranging from ~4.5–5.0, the interior of the lysosomes is acidic compared to the slightly basic cytosol (pH 7.2).
Are contained in lysosomes and released from dying lysosomes to contribute to this process and potentially released from recruited immune cells such as macrophages and neutrophils. Under normal cellular conditions, DNases maintain cellular homeostasis by breaking down old or damaged DNA; during necrosis, these enzymes release uncontrollably ...
The lysosome is commonly referred to as the cell's recycling center because it processes unwanted material into substances that the cell can use. Lysosomes break down this unwanted matter by enzymes, highly specialized proteins essential for survival. Lysosomal disorders are usually triggered when a particular enzyme exists in too small an ...
Cell damage (also known as cell injury) is a variety of changes of stress that a cell suffers due to external as well as internal environmental changes. Amongst other causes, this can be due to physical, chemical, infectious, biological, nutritional or immunological factors.
[59] [60] [61] These early-invading, phagocytic macrophages reach their highest concentration about 24 hours following the onset of some form of muscle cell injury or reloading. [62] Their concentration rapidly declines after 48 hours. [60] The second group is the non-phagocytic types that are distributed near regenerative fibers.
The inability to break down glycogen within the lysosomes of cells leads to progressive muscle weakness throughout the body and affects various body tissues, particularly in the heart, skeletal muscles, liver and the nervous system. GSD-II and Danon disease are the only glycogen storage diseases characterised by a defect in lysosomal metabolism.