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Image of a solitary fibrous tumour that is most likely a hemangiopericytoma. It surrounds a staghorn-shaped blood vessel, which results from the arrangement of pericytes around the vessel. Hemangiopericytoma is a rare vascular neoplasm, or abnormal growth, that may either be benign or malignant. In its malignant form, metastasis to the lungs ...
The cell body of pericytes has a round shape extending a few processes in a longitudinal fashion along the capillaries. Recently, efforts have been undertaken using single cell sequencing on mural cells to try to characterize their molecular signature along the blood vessels. [ 5 ]
Most vessels of the microcirculation are lined by flattened cells of the endothelium and many of them are surrounded by contractile cells called pericytes.The endothelium provides a smooth surface for the flow of blood and regulates the movement of water and dissolved materials in the interstitial plasma between the blood and the tissues.
It has been well established that smooth muscle-like pericytes play an important role in stabilizing newly formed blood vessels. Pericytes present in the stroma of tumors of breast cancer patients express MMP-9. [44] Animal models deficient of MMP-9 display disturbed recruitment of pericytes. [45]
Hemangiopericytomas are tumors that are derived from specialized spindle shaped cells called pericytes, which line capillaries. [4] Hemangiopericytoma is an aggressive mesenchymally derived tumor with oval nuclei with scant cytoplasm. There is dense intercellular reticulin staining. Tumor cells can be fibroblastic, myxoid, or pericytic. These ...
A precapillary sphincter is a band of contractile mural cells either classified as smooth muscle or pericytes that adjusts blood flow into capillaries.They were originally described in the mesenteric microcirculation, and were thought to only reside there.
Atherosclerosis is characterized by the build-up of plaque inside your blood vessels. It can lead to stenosis, which is a narrowing of your artery walls. Plaque is a fatty substance made up of:
The blood supply and direction of flow in the hypophyseal portal system has been studied over many years on laboratory animals and human cadaver specimens with injection and vascular corrosion casting methods. Short portal vessels between the neural and anterior pituitary lobes provide an avenue for rapid hormonal exchange.