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It is an imidazopyridine and increases GABA effects in the central nervous system by binding to GABA A receptors at the same location as benzodiazepines. [11] In 2025, it became known that it also suppresses the norepinephrine effect and reduces glymphatic flow , i.e. it suppresses the brain's waste disposal, [ 21 ] which explains some of its ...
[9] [10] [11] The inhibitory neurotransmitter GABA plays a complex role in modulating anxiety and stress, regulating sleep, circadian rhythms, mood, cognition, and perception. Low GABA levels are associated with emotional and behavioral disruptions, including short-term and/or long-term stress, anxiety disorders, and sleep disorders. [12]
Some studies have indicated that GABA tea consumption can also decrease stress. [10] A 2020 review in Frontiers in Neuroscience found that oral GABA intake "may have beneficial effects on stress and sleep", but also stated that further research is needed. [11]
Sleepiness and dizziness are the most common side effects. Serious side effects include respiratory depression, and allergic reactions. [7] As with all other antiepileptic drugs approved by the FDA, gabapentin is labeled for an increased risk of suicide. Lower doses are recommended in those with kidney disease. [7]
Side effects of brexanolone may include sedation, sleepiness, dry mouth, hot flashes, and loss of consciousness. [ 6 ] [ 11 ] It is a neurosteroid and acts as a positive allosteric modulator of the GABA A receptor , the major biological target of the inhibitory neurotransmitter γ-aminobutyric acid (GABA).
Gamma-aminobutyric acid, a GABA-B receptor agonist. A GABA receptor agonist is a drug that is an agonist for one or more of the GABA receptors, producing typically sedative effects, and may also cause other effects such as anxiolytic, anticonvulsant, and muscle relaxant effects. [1] There are three receptors of the gamma-aminobutyric acid. The ...
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