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Botulinum toxin, or botulinum neurotoxin (commonly called botox), is a neurotoxic protein produced by the bacterium Clostridium botulinum and related species. [24] It prevents the release of the neurotransmitter acetylcholine from axon endings at the neuromuscular junction , thus causing flaccid paralysis . [ 25 ]
In all cases, illness is caused by the botulinum toxin which the bacterium C. botulinum produces in anaerobic conditions and not by the bacterium itself. The pattern of damage occurs because the toxin affects nerves that fire (depolarize) at a higher frequency first. [12] Mechanisms of entry into the human body for botulinum toxin are described ...
Along with some strains of Clostridium butyricum and Clostridium baratii, these bacteria all produce the toxin. [2] Botulinum toxin can cause botulism, a severe flaccid paralytic disease in humans and other animals, [3] and is the most potent toxin known to science, natural or synthetic, with a lethal dose of 1.3–2.1 ng/kg in humans. [4] [5]
The botulinum toxin causes paralysis of the hindlimb muscles, resulting in immobilization of the animal, followed by muscle mass loss and a decline in bone density.
Collagen is the most prevalent protein in the human body. It plays a vital role in maintaining the skin’s structure and elasticity. ... Botulinum toxin is a neurotoxic ingredient used in ...
Some of these species produce harmful toxins such as botulinum toxin and tetanus toxin among others. Most Clostridium species that do have toxins typically have binary toxins with the first unit involved in getting the toxin into the cell and the second unit cause cellular stress or deformation. [ 6 ]
This allows the body to detect the harmful toxin if it is encountered later, and to eliminate it before it can cause harm to the host. Toxins of this type include cholera toxin , pertussis toxin , Shiga toxin and heat-labile enterotoxin from E. coli .
Clostridium species are readily found inhabiting soils and intestinal tracts. Clostridium species are also a normal inhabitant of the healthy lower reproductive tract of females. [14] The main species responsible for disease in humans are: [15] Clostridium botulinum can produce botulinum toxin in food or wounds and can cause botulism.