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Threshold limit value − time-weighted average (TLV-TWA): The average exposure on the basis of a 8 hours per day, 40 hours per week work schedule. Threshold limit value − short-term exposure limit (TLV-STEL): A 15-minute TWA exposure that should not be exceeded at any time during a workday, even if the 8-hour TWA is within the TLV-TWA.
Low-threshold spikes (LTS) refer to membrane depolarizations by the T-type calcium channel. LTS occur at low, negative, membrane depolarizations. They often follow a membrane hyperpolarization, which can be the result of decreased excitability or increased inhibition. LTS result in the neuron reaching the threshold for an action potential.
In pharmacology, the term ceiling effect refers to the property of increasing doses of a given medication to have progressively smaller incremental effect (an example of diminishing returns). Mixed agonist-antagonist opioids , such as nalbuphine , serve as a classic example of the ceiling effect; increasing the dose of a narcotic frequently ...
The two options are active high (positive logic) and active low (negative logic). Active-high and active-low states can be mixed at will: for example, a read only memory integrated circuit may have a chip-select signal that is active-low, but the data and address bits are conventionally active-high.
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Threshold dose is the minimum dose of drug that triggers minimal detectable biological effect in an animal. [1] At extremely low doses, biological responses are absent for some of the drugs. The increase in dose above threshold dose induces an increase in the percentage of biological responses. [ 2 ]
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