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Asymmetric Diels-Alder reaction is one step in the biosynthesis of the statin lovastatin. [60] The retro-Diels–Alder reaction is used in the industrial production of cyclopentadiene. Cyclopentadiene is a precursor to various norbornenes, which are common monomers. The Diels–Alder reaction is also employed in the production of vitamin B6.
The Diels-Alder reaction is one of the most powerful transformations in synthetic chemistry. ... Altom was the third member of Corey's lab to commit suicide since ...
Otto Paul Hermann Diels (German pronunciation: [ˈɔto ˈdiːls] ⓘ; 23 January 1876 – 7 March 1954) was a German chemist. His most notable work was done with Kurt Alder on the Diels–Alder reaction, a method for cyclohexene synthesis. [1] The pair was awarded the Nobel Prize in Chemistry in 1950 for their work.
The Diels-Alder reaction is perhaps the most important and commonly taught cycloaddition reaction. Formally it is a [4+2] cycloaddition reaction and exists in a huge range of forms, including the inverse electron-demand Diels–Alder reaction, hexadehydro Diels–Alder reaction and the related alkyne trimerisation.
Alberto retro-diels-alder examples. With the development of this retro Diels-Alder method for synthesis of 99m Tc and Re complexes in aqueous media by the Alberto lab, The labeling of biomolecules with piano-stool like complexes is now possible. Enabling access to the development of novel radiopharmaceuticals.
The aza Diels-Alder reaction may occur either by a concerted or stepwise process. The lowest-energy transition state for the concerted process places the imine lone pair (or coordinated Lewis acid) in an exo position. Thus, (E) imines, in which the lone pair and larger imine carbon substituent are cis, tend to give exo products. [2]
The inverse electron demand Diels–Alder reaction, or DA INV or IEDDA [1] is an organic chemical reaction, in which two new chemical bonds and a six-membered ring are formed. It is related to the Diels–Alder reaction , but unlike the Diels–Alder (or DA) reaction, the DA INV is a cycloaddition between an electron-rich dienophile and an ...
Formally, the hexadehydro Diels–Alder reaction describes only the formation of the benzyne, but this species is an unstable intermediate that reacts readily with a variety of trapping partners, including reaction solvents. Thus, in practice the HDDA reaction describes a two-step cascade reaction of benzyne formation and trapping to yield the ...