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A cardiac stress test is a cardiological examination that evaluates the cardiovascular system's response to external stress within a controlled clinical setting. This stress response can be induced through physical exercise (usually a treadmill) or intravenous pharmacological stimulation of heart rate.
Initial experiments involved a single-stage test, in which subjects walked for 10 minutes on the treadmill at a fixed workload. Bruce's first reports on treadmill exercise tests, published in 1949, analyzed minute-by-minute changes in respiratory and circulatory function of normal adults and patients with heart or lung disease. [8] [9]
The Harvard step test, in scientific literature sometimes referred to as the Brouha Test, is a type of cardiac stress test for detecting and diagnosing cardiovascular disease. It is also a good measurement of fitness and a person's ability to recover after a strenuous exercise by checking the recovery rate.
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With a maximal stress test the level of exercise is increased until the person's heart rate will not increase any higher, despite increased exercise. A fairly accurate estimate of the target heart rate, based on extensive clinical research, can be estimated by the formula 220 beats per minute minus patient's age.
Angina index will be zero if no pain appears during the exercise, one if the pain is limited to the exercise period but the patient can continue the exercise (typical angina), and two if a limiting pain occurs which is a reason to stop the exercise test. [2] [3] Duke treadmill scores typically range from -25 (highest risk) to +15 (lowest risk).
For instance, the PDZRN4 gene, which may function as a tumor suppressor, and ALPK2, a gene associated with cancer and heart health in animal models, stood out as potential markers of aging.
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