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Pavlovian fear conditioning is a behavioral paradigm in which organisms learn to predict aversive events. [1] It is a form of learning in which an aversive stimulus (e.g. an electrical shock) is associated with a particular neutral context (e.g., a room) or neutral stimulus (e.g., a tone), resulting in the expression of fear responses to the originally neutral stimulus or context.
In fear conditioning, the main circuits that are involved are the sensory areas that process the conditioned and unconditioned stimuli, certain regions of the amygdala that undergo plasticity (or long-term potentiation) during learning, and the regions that bear an effect on the expression of specific conditioned responses.
Stephen Andrew Maren (born November 7, 1967) is an American behavioral neuroscientist investigating the brain mechanisms of emotional memory, particularly the role context plays in the behavioral expression of fear. [1] He has discovered brain circuits regulating context-dependent memory, including mapping functional connections between the ...
The pattern of induced and repressed genes within neurons appears to provide a molecular basis for forming this first transient memory of this training event in the hippocampus of the rat brain. [48] When similar contextual fear conditioning is applied to a mouse, one hour after contextual fear conditioning there were 675 demethylated genes and ...
Contextual fear conditioning in the mouse causes the mouse to have a long-term memory and fear of the location in which it occurred. Contextual fear conditioning causes hundreds of DSBs in mouse brain medial prefrontal cortex (mPFC) and hippocampus neurons (see Figure: Brain regions involved in memory formation).
Furthermore, if there is a traumatic incident that is associated to a memory, and that becomes suppressed, the amygdala is responsible for this fear conditioning. The amygdala leads to the caudate nucleus in the neocortex of the basal ganglia, so the fear response can also be triggered via spontaneous recovery. Basically, the stronger the ...
Brain regions involved in memory formation including medial prefrontal cortex (mPFC) Contextual fear conditioning in the mouse causes the mouse to have a long-term memory and fear of the location in which it occurred. This conditioning causes hundreds of gene-associated DSBs in the medial prefrontal cortex (mPFC) and hippocampus that are ...
Changes in synaptic function (i.e., synaptic plasticity) are required for learning and memory [4] As evidence of this, a line of mice with a targeted disruption of the α and δ isoforms of CREB showed intact short-term memory, but disrupted long-term memory in several behavioral tasks, including contextual conditioning and spatial learning in ...