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Radiation-induced brain edema (RIBE) is a potentially life-threatening complication of brain tissue radiation and is characterized radiation necrosis, endothelial cell dysfunction, increased capillary permeability, and breakdown of the blood–brain barrier. [13] Symptoms include headache, seizure, psychomotor slowing, irritability, and focal ...
Transcranial Doppler ultrasonography (TCD), which measures cerebral blood flow velocity (CBFV) in the large intracranial arteries in the brain, has been shown in various studies to be an effective tool to diagnose children with sickle cell anemia at increased risk of having an initial or recurrent silent stroke. The narrowing of these arteries ...
The endothelium (pl.: endothelia) is a single layer of squamous endothelial cells that line the interior surface of blood vessels and lymphatic vessels. [1] The endothelium forms an interface between circulating blood or lymph in the lumen and the rest of the vessel wall.
The name of the condition includes the word "posterior" because it predominantly, though not exclusively, affects the back of the brain (the parietal and occipital lobes). Common underlying causes are severely elevated blood pressure , kidney failure , severe infections , certain medications, some autoimmune diseases , and pre-eclampsia .
Endothelial dysfunction may be involved in the development of atherosclerosis [5] [6] [7] and may predate vascular pathology. [5] [8] Endothelial dysfunction may also lead to increased adherence of monocytes and macrophages, as well as promoting infiltration of low-density lipoprotein (LDL) in the vessel wall. [9]
The maturation of blood vessels in the brain is a critical process that occurs postnatally. [6] It involves the acquisition of key barrier and contractile properties essential for brain function. During the early postnatal phase, endothelial cells (ECs) and vascular smooth muscle cells (VSMCs) undergo significant molecular and functional changes.
The olfactory nerve may also be involved in HSE, [12] which may explain its predilection for the temporal lobes of the brain, as the olfactory nerve sends branches there. In horses, a single-nucleotide polymorphism is sufficient to allow the virus to cause neurological disease; [13] but no similar mechanism has been found in humans.
Encephalitis is inflammation of the brain. [5] The severity can be variable with symptoms including reduction or alteration in consciousness, aphasia, headache, fever, confusion, a stiff neck, and vomiting. [1] [6] Complications may include seizures, hallucinations, trouble speaking, memory problems, and problems with hearing. [1]