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Clobetasol propionate is used for the treatment of various skin disorders including eczema, herpes labialis, [16] psoriasis, and lichen sclerosus.It is also used to treat several auto-immune diseases including alopecia areata, lichen planus (auto immune skin nodules), and mycosis fungoides (T-cell skin lymphoma).
Clobetasol is a synthetic glucocorticoid corticosteroid. A propionate ester of clobetasol, clobetasol propionate , has also been marketed, and is far more widely used in comparison. [ 2 ] [ 3 ]
Clobetasone (INN [1]) is a corticosteroid used in dermatology, for treating such skin inflammation as seen in eczema, psoriasis and other forms of dermatitis, and ophthalmology. Topical clobetasone butyrate has shown minimal suppression of the hypothalamic–pituitary–adrenal axis. [2]
Treatment involves discontinuing the use of topical steroids, [2] either gradually or suddenly. [2] Counselling and cold compresses may also help. [ 2 ] Thousands of people congregate in online communities to support one another throughout the healing process, and cases have been reported in both adults and children.
For treating atopic dermatitis, newer (second generation) corticosteroids, such as fluticasone propionate and mometasone furoate, are more effective and safer than older ones. They are also generally safe and do not cause skin thinning when used intermittently to treat atopic dermatitis flare-ups.
Topical and intralesional corticosteroids, such as clobetasol propionate, have also shown to be an effective treatment for AT and AU patients. [7] [8] A controlled study comprising 28 patients found positive terminal hair growth in eight of the patients (28.5%) using a 0.05% clobetasol propionate ointment. [12]
Scientists have revived a worm that was frozen 46,000 years ago — at a time when woolly mammoths, sabre-toothed tigers and giant elks still roamed the Earth.
For mild-moderate eczema a weak steroid may be used (e.g., hydrocortisone), while in more severe cases a higher-potency steroid (e.g., clobetasol propionate) may be used. In severe cases, oral or injectable corticosteroids may be used. While these usually bring about rapid improvements, they have greater side effects.
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