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The Alberta Energy Regulator (AER) is a quasi-judicial, independent agency regulating the development of energy resources in Alberta. Headquartered in Calgary, Alberta, the AER's mandate under the Responsible Energy Development Act (REDA) is "to provide for the efficient, safe, orderly and environmentally responsible development of energy resources and mineral resources in Alberta.” [1]
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The apical ectodermal ridge (AER) is a structure that forms from the ectodermal cells at the distal end of each limb bud and acts as a major signaling center to ensure proper development of a limb. After the limb bud induces AER formation, the AER and limb mesenchyme —including the zone of polarizing activity (ZPA)—continue to communicate ...
A biologics license application (BLA) is defined by the U.S. Food and Drug Administration (FDA) as follows: The biologics license application is a request for permission to introduce, or deliver for introduction, a biologic product into interstate commerce (21 CFR 601.2). The BLA is regulated under 21 CFR 600 – 680.
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Learn how to download and install or uninstall the Desktop Gold software and if your computer meets the system requirements.
The ZPA forms where the Hox8 region joins the AER. These regions are dependent on signaling in order for the appropriate induction events to occur. The AER expresses FGF8 which induces Shh expression in the posterior mesoderm. Shh then stimulates FGF4 to be expressed in the posterior part of the AER. After these events, there is a co-dependence ...