Search results
Results from the WOW.Com Content Network
The low-density lipoprotein receptor (LDL-R) is a mosaic protein of 839 amino acids (after removal of 21-amino acid signal peptide) [5] that mediates the endocytosis of cholesterol-rich low-density lipoprotein (LDL).
Bulked segregant analysis (BSA) is a technique used to identify genetic markers associated with a mutant phenotype. This allows geneticists to discover genes conferring certain traits of interest, such as disease resistance or susceptibility. This technique involves forming two groups that display opposing phenotypes for a trait of interest.
Oxidized LDL is a general term for LDL particles with oxidatively modified structural components. As a result, from free radical attack, both lipid and protein parts of LDL can be oxidized in the vascular wall. Besides the oxidative reactions taking place in vascular wall, oxidized lipids in LDL can also be derived from oxidized dietary lipids.
Apo-E interacts significantly with the low-density lipoprotein receptor (LDLR), which is essential for the normal processing of triglyceride-rich lipoproteins. [7] In peripheral tissues, Apo-E is primarily produced by the liver and macrophages , and mediates cholesterol metabolism.
The scavenger receptor superfamily is defined by its ability to recognize and bind a broad range of common ligands.These ligands include: polyanionic ligands including lipoproteins, apoptotic cells, cholesterol ester, phospholipids, proteoglycans, ferritin, and carbohydrates. [4]
Homozygotes have LDLR activity of less than 2%, while heterozygotes have defective LDL processing with receptor activity being 2–25%, depending on the nature of the mutation. Over 1000 different mutations are known. [4] There are five major classes of FH due to LDLR mutations: [12] Class I: LDLR is not synthesized at all.
Get AOL Mail for FREE! Manage your email like never before with travel, photo & document views. Personalize your inbox with themes & tabs. You've Got Mail!
A bispecific monoclonal antibody (BsMAb, BsAb) is an artificial protein that can simultaneously bind to two different types of antigen or two different epitopes on the same antigen. [1] Naturally occurring antibodies typically only target one antigen.