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N-Hydroxysuccinimide (NHS) is an organic compound with the formula (CH 2 CO) 2 NOH. It is a white solid that is used as a reagent for preparing active esters in peptide synthesis. It can be synthesized by heating succinic anhydride with hydroxylamine or hydroxylamine hydrochloride .
In this usage, a leaving group is a less formal but more commonly used synonym of the term nucleofuge. In this context, leaving groups are generally anions or neutral species, departing from neutral or cationic substrates, respectively, though in rare cases, cations leaving from a dicationic substrate are also known. [3]
Amine reactive: BS3 is amine-reactive in that its N-hydroxysulfosuccinimide (NHS) esters at each end react specifically with primary amines to form stable amide bonds in a nucleophilic acyl substitution-type reaction in which the N-hydroxysulfosuccinimide acts as the leaving group. [9]
More staff falling into debt and turning to foodbanks to feed their families, study suggests.
EDC couples primary amines, and other nucleophiles, [5] to carboxylic acids by creating an activated ester leaving group. First, the carbonyl of the acid attacks the carbodiimide of EDC, and there is a subsequent proton transfer.
Transgender men and women are increasingly having crucial hormone treatment withdrawn by NHS doctors, ... a trans-led research group, said their GPs had cited lack of policy or personal beliefs as ...
Patients of the doctors leaving Linden Medical Group took to social media to seek answers about their future health care, Joe Gonzalez, a patient of one of the doctors, said in a phone interview.
Pages in category "Leaving groups" The following 15 pages are in this category, out of 15 total. This list may not reflect recent changes. ...