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The human Y chromosome showing the SRY gene which codes for a protein regulating sexual differentiation. Sexual differentiation in humans is the process of development of sex differences in humans. It is defined as the development of phenotypic structures consequent to the action of hormones produced following gonadal determination. [1]
5α-reductase deficiency (5-ARD) – an autosomal recessive condition caused by a mutation of the 5-alpha reductase type 2 gene. It only affects people with Y chromosomes, namely genetic males. People with this condition are fertile, with the ability to father children, but may be raised as females due to ambiguous or feminized genitalia. [18] [19]
Although there is a wide range of normal ages, females typically begin the process of puberty around age 10½; males at ages 11½—12. Puberty generally ends between 15—17 for females and 16–17 for males. [1] [2] [3] Females attain reproductive maturity about four years after the first physical changes of puberty appear. [13]
Hair colors can change well into puberty, as some genes aren't "switched on" until the hormones flood the body in adolescence. Eventually, usually in the 30s, human hair stops producing melanin ...
Although early puberty in boys is not common, studies suggest that the average age of puberty in boys decreased between 1993 to 2008. The researchers attributed the early onset of puberty in boys ...
Most of the changes of virilization are produced by androgens. Virilization is a medical term commonly used in three medical and biology of sex contexts: prenatal biological sexual differentiation , the postnatal changes of typical chromosomal male (46, XY) puberty , and excessive androgen effects in typical chromosomal females (46, XX).
In girls, puberty and periods normally start between the ages of 10 to 15, but experts say this has been getting earlier in recent decades. In girls, puberty and periods normally start between the ...
The transformation of a phenotypically female child into a phenotypically male adult at puberty, which is reported to be celebrated in Dominican culture, is the result of a genotypic male (with XY chromosomes) born with a deficiency in the enzyme 5α-reductase. 5α-Reductase is responsible for the reduction of testosterone to dihydrotestosterone.