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  2. Stem cell transplantation for articular cartilage repair

    en.wikipedia.org/wiki/Stem_cell_transplantation...

    There are five types of stem cells, and MSC's are multi-potent, meaning they are cells that have the ability to develop into more than one type of specialized cell. Mesenchymal stem cells were originally discovered and studied as fibroblast-colony-forming cells in guinea-pig bone marrow and spleen cells by Friedenstein in the 1970s. [8] This ...

  3. Knee cartilage replacement therapy - Wikipedia

    en.wikipedia.org/wiki/Knee_cartilage_replacement...

    Because mesenchymal stem cells may regenerate cartilage, cartilage growth in human knees using autologous cultured mesenchymal stem cells is under research and preliminary clinical use, and appears to be safe as of 2016. [11] An advantage to this approach is that a person's own stem cells are used, avoiding tissue rejection by the immune system ...

  4. Microfracture surgery - Wikipedia

    en.wikipedia.org/wiki/Microfracture_surgery

    However, acute traumatic osteochondral lesions or surgically created lesions extending into subchondral bone, e.g. by Pridie drilling, [2] spongialization [3] abrasion [4] or microfracture causing the release of multipotent mesenchymal stem cells from the bone marrow, may heal with repair tissue consisting of fibrous tissue, fibrocartilage or ...

  5. Stem-cell therapy - Wikipedia

    en.wikipedia.org/wiki/Stem-cell_therapy

    Another stem-cell therapy, called Prococvhymal, was conditionally approved in Canada in 2012 for the management of acute graft-vs-host disease in children who are unresponsive to steroids. [9] It is an allogenic stem therapy based on mesenchymal stem cells (MSCs) derived from the bone marrow of adult donors. MSCs are purified from the marrow ...

  6. Clinical uses of mesenchymal stem cells - Wikipedia

    en.wikipedia.org/wiki/Clinical_uses_of...

    In mesenchymal stem cell therapy, most of the cells are extracted from the adult patient's bone marrow [2] [3] Mesenchymal stem cells can be obtained via a procedure called bone marrow aspiration. A needle is inserted into the back of the patients hip bone and cells are removed to be grown under controlled in vitro conditions in a lab. Over a ...

  7. Mesenchymal stem cell - Wikipedia

    en.wikipedia.org/wiki/Mesenchymal_stem_cell

    Mesenchymal stem cells (MSCs), also known as mesenchymal stromal cells or medicinal signaling cells, are multipotent stromal cells that can differentiate into a variety of cell types, including osteoblasts (bone cells), chondrocytes (cartilage cells), myocytes (muscle cells) and adipocytes (fat cells which give rise to marrow adipose tissue).

  8. Autologous chondrocyte implantation - Wikipedia

    en.wikipedia.org/wiki/Autologous_Chondrocyte...

    Techniques such as the EELS-TALC [4] to enhance ACI and its next generation advancement called Matrix Assisted Chondrocyte Implantation (MACI) [5] with enabling chondrocytes to be tissue engineered with long term native knee cartilage phenotype maintenance in vitro and in vivo, [6] [7] with the engineered tissue construct containing stem cell progenitors [8] along with those expressing ...

  9. Gene therapy for osteoarthritis - Wikipedia

    en.wikipedia.org/wiki/Gene_therapy_for...

    Genes may be delivered to synovium in animal models of RA and OA by direct, in vivo injection of vector or by indirect, ex vivo methods involving autologous synovial cells, skin fibroblasts, or other cell types such as mesenchymal stem cells. Synoviocytes, which are the predominant cell type in the synovium are closely related to fibroblasts ...

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