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The melanocyte-stimulating hormones, known collectively as MSH, also known as melanotropins or intermedins, are a family of peptide hormones and neuropeptides consisting of α-melanocyte-stimulating hormone (α-MSH), β-melanocyte-stimulating hormone (β-MSH), and γ-melanocyte-stimulating hormone (γ-MSH) that are produced by cells in the pars intermedia of the anterior lobe of the pituitary ...
α-Melanocyte-stimulating hormone (α-MSH) is an endogenous peptide hormone and neuropeptide of the melanocortin family, with a tridecapeptide structure and the amino acid sequence Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH 2.
The melanocortin 1 receptor (MC1R), also known as melanocyte-stimulating hormone receptor (MSHR), melanin-activating peptide receptor, or melanotropin receptor, is a G protein–coupled receptor that binds to a class of pituitary peptide hormones known as the melanocortins, which include adrenocorticotropic hormone (ACTH) and the different forms of melanocyte-stimulating hormone (MSH).
The pars intermedia secretes α-melanocyte-stimulating hormone (α-MSH), and corticotropin-like intermediate peptide. [ citation needed ] It appears to be tonically inhibited by the hypothalamus . In the human fetus , this area produces melanocyte stimulating hormone (MSH) which causes the release of melanin produced in melanocytes that can ...
γ-Melanocyte-stimulating hormone (γ-MSH) is an endogenous peptide hormone and neuropeptide. [1] It is a melanocortin, specifically, one of the three types of melanocyte-stimulating hormone (MSH), and is produced from proopiomelanocortin (POMC). [1] It is an agonist of the MC 1, MC 3, MC 4, and MC 5 receptors. [1]
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A melanotroph (or melanotrope) is a cell in the pituitary gland that generates melanocyte-stimulating hormone (α‐MSH) from its precursor pro-opiomelanocortin. Chronic stress can induce the secretion of α‐MSH in melanotrophs and lead to their subsequent degeneration. [1]