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Of the 660,000 congenital syphilis cases reported in 2016, 143,000 resulted in deaths of unborn babies, 61,000 deaths of newborn babies, 41,000 low birth weights or preterm births, and 109,000 young children diagnosed with congenital syphilis. [15] Around 75% were from the WHO's African and Eastern Mediterranean regions. [2]
Treponema pallidum, formerly known as Spirochaeta pallida, is a microaerophilic, gram-negative, spirochaete bacterium with subspecies that cause the diseases syphilis, bejel (also known as endemic syphilis), and yaws. [1] It is known to be transmitted only among humans and baboons. [2]
CDC says that more than 3,700 cases of congenital syphilis were reported in 2022, around 11 times the number recorded a decade ago ... Mothers can pass the infection on to their children during ...
Inflammatory involvement of tertiary syphilis begins at the adventitia of the aortic arch which progressively causes obliterative endarteritis of the vasa vasorum. [3] This leads to narrowing of the lumen of the vasa vasorum, causing ischemic injury of the medial aortic arch and then finally loss of elastic support and dilation of the vessel. [3]
With syphilis cases in U.S. newborns skyrocketing, a doctors group now recommends that all pregnant patients be screened three times for the sexually transmitted infection. The American College of ...
Involvement of the central nervous system in syphilis (either asymptomatic or symptomatic) can occur at any stage of the infection. [21] It may occur early, being either asymptomatic or in the form of syphilitic meningitis; or late as meningovascular syphilis, manifesting as general paresis or tabes dorsalis. [3]
Rates of congenital syphilis have decreased between the 1980 and 2000s due to better access to prenatal care. [16] A five-year study among 250 patients in each year among attendees in an STI clinic in West Bengal found significantly decreased(p<0.05) Syphilis prevalence from 10.8% (in 2004) to 3.6% (in 2008). [17]
Secondary syphilis. Syphilis is an STI caused by a bacterium. Untreated, it can lead to complications and death. [67] Clinical manifestations of syphilis include the ulceration of the uro-genital tract, mouth or rectum; if left untreated the symptoms worsen.