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The Hofmann rearrangement (Hofmann degradation) is the organic reaction of a primary amide to a primary amine with one less carbon atom. [ 1 ] [ 2 ] [ 3 ] The reaction involves oxidation of the nitrogen followed by rearrangement of the carbonyl and nitrogen to give an isocyanate intermediate.
An example of a Hofmann elimination (not involving a contrast between a Zaitsev product and a Hofmann product) is the synthesis of trans-cyclooctene. [4] The trans isomer is selectively trapped as a complex with silver nitrate (in this diagram the trans form looks like a cis form, but see the trans-cyclooctene article for better images):
The Hofmann rearrangement is a decarbonylation reaction whereby an amide is converted to an amine by way of an isocyanate intermediate. It is usually carried out under strongly basic conditions. It is usually carried out under strongly basic conditions.
The Hofmann–Martius rearrangement in organic chemistry is a rearrangement reaction converting an N-alkylated aniline to the corresponding ortho and / or para aryl-alkylated aniline. The reaction requires heat, and the catalyst is an acid like hydrochloric acid .
This image is a derivative work of the following images: File:Hoffmann_rearrangement_mechanism.png licensed with PD-self 2006-02-24T19:04:49Z Calvero 2575x741 (10945 Bytes) *Selfmade with ChemDraw [[Category:Name reactions]]
In organic chemistry, a rearrangement reaction is a broad class of organic reactions where the carbon skeleton of a molecule is rearranged to give a structural isomer of the original molecule. [1] Often a substituent moves from one atom to another atom in the same molecule, hence these reactions are usually intramolecular.
In organic chemistry, an electrocyclic reaction is a type of pericyclic, rearrangement reaction where the net result is one pi bond being converted into one sigma bond or vice versa. [1] These reactions are usually categorized by the following criteria: Reactions can be either photochemical or thermal.
R. P. Deshpande and U. R. Nayak [37] reported that the Hofmann–Löffler–Freytag reaction is applicable to the synthesis of pyrrolidines containing a longifolene nucleus, e.g. 62. An outstanding application of the Hofmann–Löffler–Freytag reaction is found in the preparation of the steroidal alkaloid derivatives. J.