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Cipaglucosidase alfa, sold under the brand name Pombiliti, and used in combination with miglustat, is a medication used for the treatment of glycogen storage disease type II (Pompe disease). [ 4 ] [ 5 ] Cipaglucosidase alfa is a recombinant human acid α-glucosidase enzyme replacement therapy that provides an exogenous source of acid α ...
Miglustat, sold under the brand name Zavesca among others, is a medication used to treat type I Gaucher disease [7] and Pompe disease. [10]It was approved for medical use in the European Union in November 2002, [7] [11] and for medical use in the United States in July 2003.
The safety and efficacy of Myozyme were assessed in two separate clinical trials in 39 infantile-onset patients with Pompe disease ranging in age from 1 month to 3.5 years at the time of the first infusion. [8] Myozyme treatment prolongs ventilator-free survival and overall survival. Early diagnosis and early treatment lead to much better outcomes.
According to government guidelines, fruit and vegetables should form the cornerstone of your diet. Yet the reality is that a mere 12% of adults meet the recommended 1.5-2 cups of fruit daily ...
Daflon plays a crucial role in the prevention of perivascular edema formation and treatment of venous stasis. This activity can be explained by its antagonist activity against prostaglandin E2 (PgE2) and thromboxane (TxA2) biosynthesis leading to inhibition of inflammatory process. Moreover, it also has a contraction activity on the lymphatic ...
There are three ways to test if a fruit interacts with drugs: Test a drug–fruit combination in humans [11] Test a fruit chemically for the presence of the interacting polyphenol compounds; Test a fruit genetically for the genes needed to make the interacting polyphenol compounds [32] The first approach involves risk to trial volunteers.
Pome fruits consist of a central "core" containing multiple small seeds, which is enveloped by a tough membrane and surrounded by an edible layer of flesh. [1] Pome fruit trees are deciduous, and undergo a dormant winter period that requires cold temperatures to break dormancy in spring. [1] Well-known pomes include the apple, pear, and quince. [1]
The levels of the toxin decrease over time though from approximately 1000 ppm to around 0.1 ppm in the mature fruit. [ 4 ] Relatives of Ackee, including lychee , longan , and rambutan , can contain enough α-(methylenecyclopropyl)glycine, a homologue of hypoglycin A, in their fruit to cause hypoglycemic encephalopathy in undernourished children ...
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