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Clinical studies suggest that compounds that increase the concentration in the synaptic cleft of both norepinephrine and serotonin are more successful than single acting agents in the treatment of depression, but the data is not conclusive whether SNRIs are a more effective treatment option over SSRIs for depression. [32] [33] [34]
13.4 Over-the-counter. 14 Adjunctive treatments. ... This is a complete list of clinically approved prescription antidepressants throughout the world, ...
Research regarding the effectiveness of antidepressants for depression in adults is controversial and has found both benefits [14] and drawbacks. [15] Meanwhile, evidence of benefit in children and adolescents is unclear, [16] [17] even though antidepressant use has considerably increased in children and adolescents in the 2000s. [18]
Some people may need antidepressants for a relatively short period (like while grieving the loss of a loved one), or they might need medication long-term, if the depression is chronic.
With more chronic forms of depression, the most effective treatment is often considered to be a combination of medication and psychotherapy. [6] [9] Psychotherapy is the treatment of choice in people under 18. [8] A meta-analysis examined the effectiveness of psychotherapy for depression across ages from younger than 13 years to older than 75 ...
In 2018, a systematic review and network meta-analysis comparing the efficacy and acceptability of 21 antidepressant drugs showed escitalopram to be one of the most effective. They showed that "In terms of efficacy, all antidepressants were more effective than placebo, with odds ratios (ORs) ranging between 2.13 (95% credible interval [CrI] 1. ...
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