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Induced pluripotent stem cell taken from blood cell and converted in retinal pigment epithelium. Stem cell therapy for macular degeneration is an emerging treatment approach aimed at restoring vision in individuals suffering from various forms of macular degeneration, particularly age-related macular degeneration (AMD). [1]
Two clinical trials involving derivatives of human embryonic stem cells were approved in 2010. Advanced Cell Technology (ACT) located in Marlborough, Massachusetts, leads the trials aimed at improving the vision of patients with Stargardt's Macular Dystrophy and Dry Age-Related Macular Degeneration.
Masayo Takahashi (高橋 政代, Takahashi Masayo, born June 23, 1961) is a Japanese medical physician, ophthalmologist and stem cell researcher.. Takahashi serves as a project research leader at the Riken Center for Developmental Biology in Kobe focusing on the clinical application of iPS Cell (induced Pluripotent Stem Cell) technology on macular degeneration.
The agency has specifically warned against claims that stem cells can be used to treat autism, macular degeneration, blindness, chronic pain, fatigue; neurological disorders such as multiple ...
On November 30, 2010, Ocata filed an Investigational New Drug application with the U.S. FDA for the first clinical trial using embryonic stem cells to regenerate retinal pigment epithelium to treat Dry Age-Related Macular Degeneration (Dry AMD). [17]
Lanza's team at Advanced Cell Technology were able to generate retinal pigmented epithelium cells from stem cells, and subsequent studies found that these cells could restore vision in animal models of macular degeneration. [21] [22] With this technology, some forms of blindness could potentially be treatable. [23]
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