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In the early 20th century, scarlet fever was a leading cause of death in children, but even before World War II and the introduction of antibiotics, its severity was already declining. This decline is suggested to be due to better living conditions, the introduction of better control measures, or a decline in the virulence of the bacteria.
Treatment with antibiotics shortens the duration of the acute illness by about 16 hours. [13] The primary reason for treatment with antibiotics is to reduce the risk of complications such as rheumatic fever and retropharyngeal abscesses. [13] Antibiotics prevent acute rheumatic fever if given within 9 days of the onset of symptoms. [16]
Guidance on scarlet fever outbreaks says antibiotics can be given on a case-by-case basis. Skip to main content. 24/7 Help. For premium support please call: 800-290-4726 ...
Enterocolitis is common in children. Sepsis occasionally occurs; it primarily occurs in patients with preexisting comorbidities such as diabetes mellitus, liver cirrhosis, or hemochromatosis . Postinfective complications include reactive arthritis, erythema nodosum , iritis , and glomerulonephritis .
Penicillin, an antibiotic, is the drug of choice for the treatment of scarlet fever as for any other S. pyogenes infection. For those who are allergic to penicillin, the antibiotics erythromycin or clindamycin can be used. However, occasional resistance to these drugs has been reported. [16]
SpeB was identified in 1919 as an ectoenzyme secreted by certain strains of streptococci. [11] It was originally studied as two separate toxins, streptococcal pyrogenic exotoxin B and streptococcal cysteine proteinase, until it was shown that both proteins were encoded by the speB gene and that the attributed pyrogenic activities were due to contamination by SpeA and SpeC.
Like other antibiotics, cefalexin cannot treat viral infections, such as the flu, common cold or acute bronchitis. [4] Cefalexin can be used in those who have mild or moderate allergies to penicillin. [4] However, it is not recommended in those with severe penicillin allergies. [4] Common side effects include stomach upset and diarrhea. [4]
The UK Health Security Agency (UKHSA) said that an average of 2,861 (range 479 to 5,051) of scarlet fever were recorded during the same period over the past 5 years. [ 3 ] The following table shows the number of notifications of iGAS and scarlet fever published by data from the UKHSA from 12 September to 18 June.
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