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2. Rivaroxaban - Wikipedia

   en.wikipedia.org/wiki/Rivaroxaban

   Rivaroxaban, sold under the brand name Xarelto among others, is an anticoagulant medication (blood thinner) used to treat and prevent blood clots. [8] Specifically it is used to treat deep vein thrombosis and pulmonary emboli and prevent blood clots in atrial fibrillation and following hip or knee surgery. [ 8 ]

3. Direct factor Xa inhibitors - Wikipedia

   en.wikipedia.org/wiki/Direct_factor_Xa_inhibitors

   Antistasin, the first discovered naturally occurring direct Xa inhibitor Rivaroxaban, the first synthetic direct Xa inhibitor marketed as a drug Prior to the introduction of direct factor Xa inhibitors, vitamin K antagonists such as warfarin were the only oral anticoagulants for over 60 years, and together with heparin have been the main blood ...

4. Andexanet alfa - Wikipedia

   en.wikipedia.org/wiki/Andexanet_alfa

   Andexanet alfa, sold under the brand name Andexxa among others, is an antidote for the medications rivaroxaban and apixaban, when reversal of anticoagulation is needed due to uncontrolled bleeding. [8] It has not been found to be useful for other factor Xa inhibitors. [9] It is given by injection into a vein. [9]

5. Discovery and development of direct Xa inhibitors - Wikipedia

   en.wikipedia.org/wiki/Discovery_and_development...

   Rivaroxaban. During the SAR development of rivaroxaban, researchers realized that adding a 5-chlorothiophene-2-carboxamide group to the oxazolidonine core could increase the potency by 200 fold, which had previously been too weak for medical use. In addition to this discovery, a clear preference for the (S)-configuration was confirmed.

6. Bayer's patent for blood thinner Xarelto invalid, UK ... - AOL

   www.aol.com/news/bayers-patent-blood-thinner...

   Bayer's patent covering its best-selling blood thinner Xarelto is invalid, London's High Court ruled on Friday in a blow to the German drugmaker. The company's blockbuster Xarelto drug generated ...

7. Portola Pharmaceuticals - Wikipedia

   en.wikipedia.org/wiki/Portola_Pharmaceuticals

   Andexanet alfa (Andexxa), a coagulation factor Xa (recombinant), inactivated-zhzo, the first and only antidote for patients treated with the new oral anticoagulants (NOACs) rivaroxaban and apixaban when a reversal of anticoagulation is required due to life-threatening or uncontrolled bleeding.

8. Mark Cuban’s Cost Plus Drugs will begin manufacturing ... - AOL

   www.aol.com/finance/mark-cuban-cost-plus-drugs...

   A doctor says a patient saved over $1,000 a month by ordering prescriptions through Mark Cuban’s online pharmacy Mark Cuban’s upstart online pharmacy just scored a big win by teaming with one ...

9. List of SJS-inducing substances - Wikipedia

   en.wikipedia.org/wiki/List_of_SJS-inducing...

   Xarelto: Sitagliptin [citation needed] Sulfonamides [2] Tetracycline [2 This page was last edited on 6 August 2024, at 09:55 (UTC). Text is available ...