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Diffuse alveolar damage (DAD) is a histologic term used to describe specific changes that occur to the structure of the lungs during injury or disease. Most often DAD is described in association with the early stages of acute respiratory distress syndrome ( ARDS ). [ 1 ]
Hypertrophic Osteodystrophy (HOD) is a bone disease that occurs most often in fast-growing large and giant breed dogs; however, it also affects medium breed animals like the Australian Shepherd. The disorder is sometimes referred to as metaphyseal osteopathy , and typically first presents between the ages of 2 and 7 months. [ 1 ]
The loose connective tissue plugs occupying the alveolar spaces often connect to other connective tissue plugs in nearby alveoli via the pores of Kohn creating a characteristic butterfly pattern on histology. [9] There is usually minimal to no interstitial inflammatory changes in biopsies of organizing pneumonia. [9]
[1] [3] There are four key features of UIP including interstitial fibrosis in a 'patchwork pattern', interstitial scarring, honeycomb changes and fibroblast foci. [citation needed] Fibroblastic foci are dense collections of myofibroblasts and scar tissue and, together with honeycombing, are the main pathological findings that allow a diagnosis ...
Alveolar lung diseases are classified as processes that affect these units that ultimately lead to issues with ventilation. There are a number of different causes of insult to the alveoli including build up of fluid, hemorrhage, infection, malignancy and build up of protein and mineral deposits.
Preservation of lung volumes in the presence of increased interstitial markings is a radiographic hallmark of LAM that helps distinguish it from most other interstitial lung diseases, in which alveolar septal and interstitial expansion tend to increase the lung's elastic recoil properties and decreased lung volumes. [citation needed]
In 1965 Liebow described 18 patients with pulmonary lesions with large alveolar cell proliferation and desquamation. Liebow also noted that the walls of the patient's distal airways were thickened. [23] The name "desquamative interstitial pneumonia" originated from the assumption that the disease was caused by epithelial cell desquamation. [1] [4]
Idiopathic interstitial pneumonia (IIP), or noninfectious pneumonia [1] are a class of diffuse lung diseases. These diseases typically affect the pulmonary interstitium, although some also have a component affecting the airways (for instance, cryptogenic organizing pneumonitis). There are seven recognized distinct subtypes of IIP. [2]