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One review of magnetic resonance spectroscopy studies reported increased choline in the basal ganglia, and cingulate as well as a decrease in NAA in the dlPFC and hippocampus. State-specific findings were reported to include elevated phosphomonoesters during acute mood states, and reduced inositol with treatment. [ 85 ]
4129 109731 Ensembl ENSG00000069535 ENSMUSG00000040147 UniProt P27338 Q8BW75 RefSeq (mRNA) NM_000898 NM_172778 RefSeq (protein) NP_000889 NP_766366 Location (UCSC) Chr X: 43.77 – 43.88 Mb Chr X: 16.58 – 16.68 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Monoamine oxidase B (MAO-B) is an enzyme that in humans is encoded by the MAOB gene. The protein encoded by this gene belongs ...
Necrosis is the death of a cell caused by external factors such as trauma or infection and occurs in several different forms. Necrosis was long seen as a non-physiological process that occurs as a result of infection or injury, [ 4 ] but in the 2000s, a form of programmed necrosis, called necroptosis , [ 5 ] was recognized as an alternative ...
Exposure to Toxoplasma gondii (seropositivity) without developing Toxoplasmosis has been proven to alter various characteristics of human behavior as well as being a causative factor in some cases of depression, [41] [42] in addition, studies have linked seropositivity with an increased rate of suicide [43]
Molecular neuroscience is a branch of neuroscience that observes concepts in molecular biology applied to the nervous systems of animals. The scope of this subject covers topics such as molecular neuroanatomy, mechanisms of molecular signaling in the nervous system, the effects of genetics and epigenetics on neuronal development, and the molecular basis for neuroplasticity and ...
[141] [142] One meta analysis of cytokines in people with MDD found increased levels of pro-inflammatory IL-6 and TNF-α levels relative to controls. [143] The first theories came about when it was noticed that interferon therapy caused depression in a large number of people receiving it. [ 144 ]
If you or someone you know is experiencing suicidal thoughts, call 911 or the 988 Suicide & Crisis Lifeline at 988 or 800-273-8255, or text HOME to the Crisis Text Line at 741741.
Neuropharmacology is a very broad region of science that encompasses many aspects of the nervous system from single neuron manipulation to entire areas of the brain, spinal cord, and peripheral nerves. To better understand the basis behind drug development, one must first understand how neurons communicate with one another. [citation needed]