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The Selenium and Vitamin E Cancer Prevention Trial, or SELECT, was a clinical trial conducted with the goal of determining whether vitamin E and selenium supplements could prevent prostate cancer. [1] Enrollment for the trial began in 2001 and ended in 2004. [1]
Dr. Marisa C. Weiss with Breastcancer.org offers insights on early-onset breast cancer, modifiable risk factors, and tips for lowering risk through nutrition and lifestyle changes.
Advertisement for a healthy diet to possibly reduce cancer risk. An average 35% of human cancer mortality is attributed to the diet of the individual. [9] Studies have linked excessive consumption of red or processed meat to an increased risk of breast cancer, colon cancer, and pancreatic cancer, a phenomenon which could be due to the presence of carcinogens in meats cooked at high temperatures.
Selenium is found in metal sulfide ores, where it substitutes for sulfur. Commercially, selenium is produced as a byproduct in the refining of these ores. Minerals that are pure selenide or selenate compounds are rare. The chief commercial uses for selenium today are glassmaking and pigments. Selenium is a semiconductor and is used in photocells.
Selenium is an essential nutrient that exhibits potent anticarcinogenic properties, and deficiency of selenium may cause certain neurologic diseases. It has been proposed that the effects of selenium in preventing cancer and neurologic diseases may be mediated by selenium-binding proteins. The exact function of this gene is not known. [6]
Methaneseleninic acid shows potential anticancer activity and is a model for studying the anticancer effects of selenium in vitro. [7] Methaneseleninic acid shows superior in vivo inhibitory efficacy toward human prostate cancer compared to selenomethionine or selenite (ion). [8]
In developed countries, about 99% of breast cancer cases are diagnosed in female patients; in a few African countries, which represent the highest incidence of male breast cancer, males account for 5–15% of cases. [4] The rate of male breast cancer appears to be rising somewhat. [9] Male breast cancer patients tend to be older than female ...
Methylselenocysteine, also known as Se-methylselenocysteine, is an analog of S-methylcysteine in which the sulfur atom is replaced with a selenium atom. It is an inhibitor of DMBA-induced mammary tumors [1] and a "chemopreventive agent that blocks cell cycle progression and proliferation of premalignant mammary lesions and induces apoptosis of cancer cell lines in culture."
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