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DESeq2 employs statistical methods to normalize and analyze RNA-seq data, making it a valuable tool for researchers studying gene expression patterns and regulation. It is available through the Bioconductor repository. It was first presented in 2014. [1] As of September 2023, its use has been cited over 30,000 times. [2]
In another usage in statistics, normalization refers to the creation of shifted and scaled versions of statistics, where the intention is that these normalized values allow the comparison of corresponding normalized values for different datasets in a way that eliminates the effects of certain gross influences, as in an anomaly time series. Some ...
NOISeq NOISeq is a non-parametric approach for the identification of differentially expressed genes from count data or previously normalized count data. NOISeq empirically models the noise distribution of count changes by contrasting fold-change differences (M) and absolute expression differences (D) for all the features in samples within the ...
The data in the following example were intentionally designed to contradict most of the normal forms. In practice it is often possible to skip some of the normalization steps because the data is already normalized to some extent. Fixing a violation of one normal form also often fixes a violation of a higher normal form.
Second normal form (2NF), in database normalization, is a normal form. A relation is in the second normal form if it fulfills the following two requirements: It is in first normal form. It does not have any non-prime attribute that is functionally dependent on any proper subset of any candidate key of the relation (i.e. it lacks partial ...
To quantile normalize two or more distributions to each other, without a reference distribution, sort as before, then set to the average (usually, arithmetic mean) of the distributions. So the highest value in all cases becomes the mean of the highest values, the second highest value becomes the mean of the second highest values, and so on.
A matrix normal form or matrix canonical form describes the transformation of a matrix to another with special properties. Pages in category "Matrix normal forms" The following 10 pages are in this category, out of 10 total.
The sixth normal form is currently as of 2009 being used in some data warehouses where the benefits outweigh the drawbacks, [9] for example using anchor modeling.Although using 6NF leads to an explosion of tables, modern databases can prune the tables from select queries (using a process called 'table elimination' - so that a query can be solved without even reading some of the tables that the ...