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Loop diuretics may also precipitate kidney failure in patients concurrently taking an NSAID and an ACE inhibitor—the so-called "triple whammy" effect. [19] Because furosemide, torsemide and bumetanide are technically sulfa drugs, there is a theoretical risk that patients sensitive to sulfonamides may be sensitive to these loop diuretics. This ...
Furosemide is primarily used for the treatment of edema, but also in some cases of hypertension (where there is also kidney or heart impairment). [14] It is often viewed as a first-line agent in most people with edema caused by congestive heart failure because of its anti-vasoconstrictor and diuretic effects.
This causes an increase in renal free water excretion (aquaresis), an increase in serum sodium concentration, a decrease in urine osmolality, and an increase in urine output. [16] 5. collecting duct: Na-H exchanger antagonists: dopamine [17] Promotes Na + excretion 2. proximal tubule [17] Carbonic anhydrase inhibitors: acetazolamide, [17 ...
Triamterene, specifically, is a potential nephrotoxin and up to half of the patients on it can have crystalluria or urinary casts. [ 12 ] [ 13 ] Due to its activity as an androgen receptor antagonist and progesterone receptor agonist, spironolactone causes adverse effects, including gynecomastia or decreased libido in males and menstrual ...
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more than 1/10 of all patients [1] hypokalaemia, which can lead to nausea, muscular weakness or cramps, and ECG abnormities; 1/100 to 1/10. hyponatraemia, which can lead to headache, nausea, drowsiness or confusion; orthostatic hypotension; initially increase of urea, uric acid and creatinine, which can lead to a gout attack in predisposed patients
The rare nature of Dent's disease makes it difficult to coordinate large controlled studies, so most evidence for thiazide use is with too few patients to make broad recommendations possible. [24] Long-term thiazide use may not be advisable due to the risk of significant adverse side effects.
In April 2005, FDA advisors requested that Pfizer place a boxed warning on their non-steroidal anti-inflammatory drug Celebrex for cardiovascular and gastrointestinal risks. [9] [10] In 2005, the FDA issued a boxed warning regarding the risk of atypical antipsychotics being prescribed among elderly patients with dementia. This advisory was ...