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While the usual dose of chloroquine used in treatment is 10 mg/kg, toxicity begins to occur at 20 mg/kg, and death may occur at 30 mg/kg. [24] In children as little as a single tablet can be fatal. [25] [16] Treatment recommendations include early mechanical ventilation, cardiac monitoring, and activated charcoal. [24]
The couple had incorrectly believed that the parasite treatment would have the same effects as the medication form of chloroquine. The surviving wife stated that the couple self-administered the chemical after listening to speeches by President Donald Trump that touted chloroquine as an effective treatment against COVID-19. [40] [41]
Chloroquine and hydroxychloroquine are anti-malarial medications also used against some auto-immune diseases. [51] Chloroquine, along with hydroxychloroquine, was an early experimental treatment for COVID-19. [52] Neither drug has been useful to prevent or treat SARS-CoV-2 infection.
Medical experts are not finding much to like in Trump's chloroquine treatment.
The FDA later clarified that it has not approved any therapeutics or drugs to treat COVID-19, but that studies were underway to see if chloroquine could be effective in treatment of COVID-19. [146] [147] Following Trump's claim, panic buying of chloroquine was reported from many countries in Africa, Latin America and South Asia. Health ...
Routes of administration are usually classified by application location (or exposition). The route or course the active substance takes from application location to the location where it has its target effect is usually rather a matter of pharmacokinetics (concerning the processes of uptake, distribution, and elimination of drugs).
Chloroquine retinopathy is a form of toxic retinopathy (damage of the retina) caused by the drugs chloroquine or hydroxychloroquine, which are sometimes used in the treatment of autoimmune disorders such as rheumatoid arthritis and systemic lupus erythematosus. This eye toxicity limits long-term use of the drugs.
Chloroquine is a water-soluble anti-malarial medication administered in the form of a tablet and is absorbed by the gastrointestinal tract. [12] Hydroxychloroquine, another anti-malarial, is used to treat quartan fever. Hydroxychloroquine is also typically administered to patients with lupus flares.