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Therefore, all patients receiving TPN must also receive biotin at the recommended daily dose, especially if TPN therapy is expected to last more than 1 week. All hospital pharmacies currently include biotin in TPN preparations. [2] Protein deficiency (not certain): A shortage of proteins involved in biotin homeostasis can cause biotin deficiency.
Mutations in the BTD gene cause biotinidase deficiency. Biotinidase is the enzyme that is made by the BTD gene. Many mutations that cause the enzyme to be nonfunctional or to be produced at extremely low levels have been identified. Biotin is a vitamin that is chemically bound to proteins. (Most vitamins are only loosely associated with proteins.)
Signs of a biotin deficiency may appear gradually, per the NIH. In the later stages, a biotin deficiency can cause: Hair thinning. Hair loss. A scaly, red rash around orifices. Dry, red eyes ...
Subclinical deficiency can cause mild symptoms, such as hair thinning, brittle fingernails, or skin rash, typically on the face. [2] [4] Aside from inadequate dietary intake (rare), biotin deficiency can be caused by a genetic disorder that affects biotin metabolism. The most common among these is biotinidase deficiency.
Discover what this essential B vitamin can do for your body and whether you need more in your diet.
n/a Ensembl n/a n/a UniProt n a n/a RefSeq (mRNA) n/a n/a RefSeq (protein) n/a n/a Location (UCSC) n/a n/a PubMed search n/a n/a Wikidata View/Edit Human Biotinidase Identifiers Symbol BTD NCBI gene 686 HGNC 1122 OMIM 609019 RefSeq NM_000060 UniProt P43251 Other data EC number 3.5.1.12 Locus Chr. 3 p25 Search for Structures Swiss-model Domains InterPro Biotinidase (EC 3.5.1.12, amidohydrolase ...
Alcoholism can also cause vitamin deficiencies. Long-term deficiencies can be life-threatening. [20] Riboflavin (Vitamin B 2) deficiency: Deficiency causes painful red tongue with sore throat, chapped and cracked lips, and inflammation at the corners of the mouth (angular cheilitis). Eyes can be itchy, watery, bloodshot and sensitive to light.
One important note: Excess biotin can also "cause incorrect results in certain laboratory tests that look at thyroid levels and blood markers that can help diagnose heart attacks," says Dr. Castillo.