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Hairy cell leukemia is an uncommon hematological malignancy characterized by an accumulation of abnormal B lymphocytes. [1] The incidence of hairy cell leukemia (HCL) is 0.28-0.30 cases per 100,000 people in Europe and the United States and the prevalence is 3 cases per 100,000 in Europe with a lower prevalence in Asia, Africa and the Middle East.
John Moore first visited UCLA Medical Center on October 5, 1976, after he was diagnosed with hairy cell leukemia.Physician and cancer researcher David Golde took samples of Moore's blood, bone marrow, and other bodily fluids to confirm the diagnosis and recommended a splenectomy because of the potentially fatal amount of swelling in Moore's spleen. [3]
Moxetumomab pasudotox, sold under the brand name Lumoxiti, is an anti-CD22 immunotoxin medication for the treatment of adults with relapsed or refractory hairy cell leukemia (HCL) who have received at least two prior systemic therapies, including treatment with a purine nucleoside analog.
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Continuing her research with hairy cell leukemia, Bouroncle worked with Ohio State investigators Michael Grever and Eric Kraut in the 1980s to develop a treatment for the disease known as deoxycoformycin. [4] She helped to found The James Cancer Hospital, which opened at Ohio State in 1990. She won several teaching-related awards at Ohio State. [1]
Estimates based on screening of leukemia-lymphoma cell lines suggest that about 15% of these cell lines are not representative of what they are usually assumed to be. [2] A project is currently underway to enumerate and rename contaminated cell lines to avoid errors in research caused by misattribution.
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As a german HCL patient I would give my respect to the english version of the Hairy cell article, which is far better than the german version and includes a lot of useful hints. After 2 therapies with cladribine ( first 10 years ago, 2nd 5 years ago) i took some infusions with CD20 rituximab last year ( first one in clinic in combination with ...