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Vitamin D is a group of fat-soluble secosteroids responsible for increasing intestinal absorption of calcium, magnesium, and phosphate, along with numerous other biological functions. [1][2] In humans, the most significant compounds within this group are vitamin D 3 (cholecalciferol) and vitamin D 2 (ergocalciferol). [2][3]
Calcifediol, also known as calcidiol, 25-hydroxycholecalciferol, or 25-hydroxyvitamin D3 (abbreviated 25 (OH)D3), [1] is a form of vitamin D produced in the liver by hydroxylation of vitamin D 3 (cholecalciferol) by the enzyme vitamin D 25-hydroxylase. [3][4][5] Calcifediol can be further hydroxylated by the enzyme 25 (OH)D-1α-hydroxylase ...
CYP2R1 is cytochrome P450 2R1, an enzyme which is the principal vitamin D 25-hydroxylase. [5] [6] In humans it is encoded by the CYP2R1 gene located on chromosome 11p15.2. [7]It is expressed in the endoplasmic reticulum in liver, where it performs the first step in the activation of vitamin D by catalyzing the formation of 25-hydroxyvitamin D. [8]
However, if you do opt to take a supplement, the National Institute of Health’s Office of Dietary Supplements says the recommended amount of vitamin D for adults 19-70 is 600 IU daily. This ...
These capsules deliver 2,000 IU of vitamin D, providing a potent dose to support your bone health and immune function. Kirkland's extra strength formula is ideal for those requiring higher levels ...
proteins. 25-Hydroxyvitamin D 1-alpha-hydroxylase (VD 1A hydroxylase) also known as calcidiol 1-monooxygenase [5] or cytochrome p450 27B1 (CYP27B1) or simply 1-alpha-hydroxylase is a cytochrome P450 enzyme that in humans is encoded by the CYP27B1 gene. [6][7][8] VD 1A hydroxylase is located in the proximal tubule of the kidney and a variety of ...
Vitamin D deficiency is typically diagnosed by measuring the concentration of the 25-hydroxyvitamin D in the blood, which is the most accurate measure of stores of vitamin D in the body. [1][7][2] One nanogram per millilitre (1 ng/mL) is equivalent to 2.5 nanomoles per litre (2.5 nmol/L). Severe deficiency: <12 ng/mL = <30 nmol/L[2] Deficiency ...
Taking a dose of 3,320 International Units (IU) of vitamin D per day was associated with benefits such as blood pressure, cholesterol, and fasting blood glucose, according to a meta-study.
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