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5-HT receptors, 5-hydroxytryptamine receptors, or serotonin receptors, are a group of G protein-coupled receptor and ligand-gated ion channels found in the central and peripheral nervous systems. [1][2][3] They mediate both excitatory and inhibitory neurotransmission. The serotonin (i.e., 5-hydroxytryptamine, hence "5-HT") receptors are ...
The neurotransmitter serotonin (illustration) has various receptors. A serotonin receptor agonist is an agonist of one or more serotonin receptors. They activate serotonin receptors in a manner similar to that of serotonin (5-hydroxytryptamine; 5-HT), a neurotransmitter and hormone and the endogenous ligand of the serotonin receptors.
15557 Ensembl ENSG00000179097 ENSMUSG00000050783 UniProt P30939 Q02284 RefSeq (mRNA) NM_000866 NM_001322208 NM_001322209 NM_001322210 NM_008310 RefSeq (protein) NP_000857 NP_001309137 NP_001309138 NP_001309139 NP_032336 Location (UCSC) Chr 3: 87.79 – 87.99 Mb Chr 16: 64.75 – 64.93 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse 5-hydroxytryptamine (serotonin) receptor 1F, also ...
The 5-HT 1 receptors are a subfamily of the 5-HT serotonin receptors that bind to the endogenous neurotransmitter serotonin (also known as 5-hydroxytryptamine, or 5-HT). [1] The 5-HT 1 subfamily consists of five G protein-coupled receptors (GPCRs) that share 40% to 63% overall sequence homology, including 5-HT 1A, 5-HT 1B, 5-HT 1D, 5-HT 1E, and 5-HT 1F. [2]
Infobox references. Serotonin (/ ˌsɛrəˈtoʊnɪn, ˌsɪərə -/) [6][7][8] or 5-hydroxytryptamine (5-HT) is a monoamine neurotransmitter. Its biological function is complex, touching on diverse functions including mood, cognition, reward, learning, memory, and numerous physiological processes such as vomiting and vasoconstriction.
[39] [40] Similarly to serotonin and related compounds like dimethyltryptamine (DMT), bufotenin is a potent agonist of the serotonin 5-HT 2A and 5-HT 2C receptors. [ 39 ] [ 40 ] It is also known to bind with high affinity to other serotonin receptors , including the serotonin 5-HT 1A , 5-HT 1B , 5-HT 1D , and 5-HT 3 receptors , and is likely to ...
Ergotamine is an agonist of the serotonin 5-HT 2B receptor and has been associated with cardiac valvulopathy. [19] Despite acting as a potent 5-HT 2A receptor agonist, ergotamine is said to be non-hallucinogenic similarly to lisuride. [20] [21] This is thought to be due to functional selectivity at the 5-HT 2A receptor.
Serotonin transporter. The serotonin transporter (SERT or 5-HTT) also known as the sodium-dependent serotonin transporter and solute carrier family 6 member 4 is a protein that in humans is encoded by the SLC6A4 gene. [5] SERT is a type of monoamine transporter protein that transports the neurotransmitter serotonin from the synaptic cleft back ...