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Wolff's law, developed by the German anatomist and surgeon Julius Wolff (1836–1902) in the 19th century, states that bone in a healthy animal will adapt to the loads under which it is placed. [1] If loading on a particular bone increases, the bone will remodel itself over time to become stronger to resist that sort of loading.
The basis of osteogenic loading stems from Wolff's law, [5] which shows that the force or loading on bone through its axis, can stimulate the bone's natural function of increasing in density. Further study has shown that greater loads on bone can stimulate a greater effect of the body to respond and increase the density of bone, and can show ...
the histological proof of micro-damages in human bone biopsies; the basic model of the adaptation of the Growth plate to mechanical stress; the Utah-Paradigm of Bone physiology (Mechanostat-Theorem), an enhancement of Wolff's law stating that Bone adapts to mechanical stress and that hence there is a close link between muscle and bone
The Mechanostat is often defined as a practical description of Wolff's law described by Julius Wolff (1836–1902), but this is not completely accurate. Wolff wrote his treatises on bone after images of bone sections were described by Culmann and von Meyer, who suggested that the arrangement of the struts (trabeculae) at the ends of the bones ...
This is known as Wolff's law, which essentially states that bone remodeling occurs to counter and adapt to loads placed upon it. [31] Mature osteoblasts are differentiated precursor cells found in the bone marrow. MSCs are typically found in the bone marrow stroma. [33] MSC differentiation is induced by a cocktail of morphogens and other factors.
Grave of Julius Wolff at the Jüdischen Friedhof, Weissensee (Berlin). His work was one of the mile stones for orthopedics as a distinct discipline in medicine. Julius Wolff was the first professor of orthopedics at the Charité and the founder and director of the first Department of Orthopaedic Surgery in Berlin. His scientific work has to ...
Bone tissue is removed by osteoclasts, and then new bone tissue is formed by osteoblasts. Both processes utilize cytokine (TGF-β, IGF) signalling.In osteology, bone remodeling or bone metabolism is a lifelong process where mature bone tissue is removed from the skeleton (a process called bone resorption) and new bone tissue is formed (a process called ossification or new bone formation).
Stress shielding is the reduction in bone density as a result of removal of typical stress from the bone by an implant (for instance, the femoral component of a hip prosthesis). [1] This is because by Wolff's law, [2] bone in a healthy person or animal remodels in response to the loads it is placed under. It is possible to mention the elastic ...