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The risk factors [110] for treatment resistant depression are: the duration of the episode of depression, severity of the episode, if bipolar, lack of improvement in symptoms within the first couple of treatment weeks, anxious or avoidant and borderline comorbidity and old age. Treatment resistant depression is best handled with a combination ...
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Reviews of behavioral activation studies for depression found that it had a positive measurable effect and that policy makers should consider it an effective treatment. [ 19 ] [ 17 ] A large-scale treatment study found behavioral activation to be more effective than cognitive therapy and on par with medication for treating depression. [ 20 ]
The World Health Organisation has stated that depression is a leading cause of disability worldwide and a major contributor to the global burden of disease. [5] Stephen Ilardi has described depression as a "disease of civilisation", stating "We were never designed for the sedentary, indoor, sleep-deprived, socially-isolated, fast-food-laden, frenetic pace of modern life".
Ketamine can be effective for people with treatment-resistant depression. Currently, anyone taking the medication needs clinical supervision, making it expensive.
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