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"The first 1000-year-old is probably only ~10 years younger than the first 150-year-old."–Aubrey de Grey, 2005 [1]. In the life extension movement, longevity escape velocity (LEV), actuarial escape velocity [2] or biological escape velocity [3] is a hypothetical situation in which one's remaining life expectancy (not life expectancy at birth) is extended longer than the time that is passing.
Longevity quotient. Longevity Quotient (LQ) is a simplified measure to enable normalized comparisons of various species' longevity. It shares some similarity with measures such as Intelligence Quotient. It originated with Steven N. Austad and Kathleen E Fischer 's 1991 paper on mammalian aging. [1][2]
Paraplegia, or paraparesis, is an impairment in motor or sensory function of the lower extremities. The word comes from Ionic Greek ( παραπληγίη ) "half-stricken". [ citation needed ] It is usually caused by spinal cord injury or a congenital condition that affects the neural (brain) elements of the spinal canal .
Biological immortality (sometimes referred to as bio-indefinite mortality) is a state in which the rate of mortality from senescence (or aging) is stable or decreasing, thus decoupling it from chronological age. Various unicellular and multicellular species, including some vertebrates, achieve this state either throughout their existence or ...
Hereditary spastic paraplegia (HSP) is a group of inherited diseases whose main feature is a progressive gait disorder. The disease presents with progressive stiffness (spasticity) and contraction in the lower limbs. [1] HSP is also known as hereditary spastic paraparesis, familial spastic paraplegia, French settlement disease, Strumpell ...
A survivorship curve is a graph showing the number or proportion of individuals surviving to each age for a given species or group (e.g. males or females). Survivorship curves can be constructed for a given cohort (a group of individuals of roughly the same age) based on a life table. There are three generalized types of survivorship curves: [1 ...
The Gompertz–Makeham law of mortality describes the age dynamics of human mortality rather accurately in the age window from about 30 to 80 years of age. At more advanced ages, some studies have found that death rates increase more slowly – a phenomenon known as the late-life mortality deceleration [2] – but more recent studies disagree.
As the cell divides, the telomeres on the ends of chromosomes shorten. The Hayflick limit is the limit on cell replication imposed by the shortening of telomeres with each division. This end stage is known as cellular senescence. The Hayflick limit has been found to correlate with the length of the telomeric region at the end of chromosomes.