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To induce general anesthesia, propofol is the drug used almost exclusively, having largely replaced sodium thiopental. [13]It is often administered as part of an anesthesia maintenance technique called total intravenous anesthesia, using either manually programmed infusion pumps or computer-controlled infusion pumps in a process called target controlled infusion (TCI).
Propofol infusion syndrome (PRIS) is a rare syndrome which affects patients undergoing long-term treatment with high doses of the anaesthetic and sedative drug propofol. It can lead to cardiac failure , rhabdomyolysis , metabolic acidosis , and kidney failure , and is often fatal.
Propofol, an anesthetic medication, confers its own antiemetic properties. Weibel, Rücker, Eberhart et al's 2020 Cochrane review demonstrated that combination therapy is more effective than single anti-emetic, and that dexamethasone and ondansetron (a commonly used combination) are two of the most effective anti-emetics for PONV.
Propofol (di-isopropyl phenol) was synthesized by Glen and colleagues in the early 1970s, [7] but its first formulations were temporarily withdrawn due to a number of adverse reactions during clinical studies. [1] In 1983, a lipid emulsion formulation of propofol was available, which carried great potential during clinical trials. [8]
“He takes me to the ER and I’m like, ‘Oh, crap, I gotta do the propofol before I’m out [and] dink, I’m back.’ We go to the ER, and for some reason, [the doctors] let him stand in the ...
On June 25, 2009, the American singer Michael Jackson died of acute propofol intoxication in Los Angeles, California, at the age of 50. His personal physician, Conrad Murray, said that he found Jackson in his bedroom at his North Carolwood Drive home in the Holmby Hills area of the city not breathing and with a weak pulse; he administered cardiopulmonary resuscitation (CPR) to no avail, and ...
Sodium thiopental is an ultra-short-acting barbiturate and has been used commonly in the induction phase of general anesthesia.Its use has been largely replaced with that of propofol, but may retain some popularity as an induction agent for rapid-sequence induction and intubation, such as in obstetrics. [12]
Propofol is given intravenously. It has been used in an acute care setting in hospital as a rescue therapy for emesis. [22] Peppermint is claimed to help nausea or stomach pain when added into a tea or peppermint candies. Muscimol is purported to have antiemetic activity. [23] Ajwain is purported to be antiemetic.