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  2. Methylenetetrahydrofolate reductase deficiency - Wikipedia

    en.wikipedia.org/wiki/Methylenetetrahydrofolate...

    MTHFR is the rate-limiting enzyme in the methyl cycle, which includes the conversion of homocysteine into methionine. Defects in variants of MTHFR can therefore lead to hyperhomocysteinemia. [9] There are two common variants of MTHFR deficiency. In the more significant of the two, the individual is homozygous for the 677T polymorphism.

  3. Methylenetetrahydrofolate reductase - Wikipedia

    en.wikipedia.org/wiki/Methylenetetrahydrofolate...

    Methylenetetrahydrofolate reductase (MTHFR) is the rate-limiting enzyme in the methyl cycle, and it is encoded by the MTHFR gene. [5] Methylenetetrahydrofolate reductase catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a cosubstrate for homocysteine remethylation to methionine. Natural variation in this ...

  4. Thrombophilia - Wikipedia

    en.wikipedia.org/wiki/Thrombophilia

    Thrombophilia (sometimes called hypercoagulability or a prothrombotic state) is an abnormality of blood coagulation that increases the risk of thrombosis (blood clots in blood vessels). [ 1 ] [ 2 ] Such abnormalities can be identified in 50% of people who have an episode of thrombosis (such as deep vein thrombosis in the leg) that was not ...

  5. Hypercoagulability in pregnancy - Wikipedia

    en.wikipedia.org/.../Hypercoagulability_in_pregnancy

    Pregnancy-induced hypercoagulability is probably a physiologically adaptive mechanism to prevent post partum hemorrhage. [1] Pregnancy changes the plasma levels of many clotting factors, such as fibrinogen, which can rise up to three times its normal value. [2] Thrombin levels increase. [3] Protein S, an anticoagulant, decreases.

  6. Coagulopathy - Wikipedia

    en.wikipedia.org/wiki/Coagulopathy

    The normal clotting process depends on the interplay of various proteins in the blood. Coagulopathy may be caused by reduced levels or absence of blood-clotting proteins, known as clotting factors or coagulation factors. Genetic disorders, such as hemophilia and Von Willebrand disease, can cause a reduction in clotting factors. [2]

  7. Antiphospholipid syndrome - Wikipedia

    en.wikipedia.org/wiki/Antiphospholipid_syndrome

    Antiphospholipid syndrome is known for causing arterial or venous blood clots, in any organ system, and pregnancy-related complications.While blood clots and pregnancy complications are the most common and diagnostic symptoms associated with APS, other organs and body parts may be affected like platelet levels, heart, kidneys, brain, and skin.

  8. Methionine synthase - Wikipedia

    en.wikipedia.org/wiki/Methionine_synthase

    The physiological resting state of the enzyme is thought to contain the enzyme-bound(Cob) cofactor in the methylcobalamin form, with the cobalt atom in the formal +3 valence state (Cob(III)-Me). The cobalamin is then demethylated by zinc -activated thiolate homocysteine, generating methionine and reducing the cofactor to a Cob(I) state.

  9. Maternal physiological changes in pregnancy - Wikipedia

    en.wikipedia.org/wiki/Maternal_physiological...

    A pregnant woman will also become hypercoagulable, leading to increased risk for developing blood clots and embolisms, such as deep vein thrombosis and pulmonary embolism. Women are 4-5 times more likely to develop a clot during pregnancy and in the postpartum period than when they are not pregnant. [25]

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