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Dabigatran, sold under the brand name Pradaxa among others, is an anticoagulant used to treat and prevent blood clots and to prevent stroke in people with atrial fibrillation. [ 6 ] [ 7 ] Specifically it is used to prevent blood clots following hip or knee replacement and in those with a history of prior clots. [ 6 ]
Direct factor Xa inhibitors (xabans) are anticoagulants (blood thinning drugs), used to both treat and prevent blood clots in veins, and prevent stroke and embolism in people with atrial fibrillation (AF). [2] [3]
In October 2010 the US FDA approved dabigatran etexilate for the prevention of stroke in patients with atrial fibrillation (AF). [ 6 ] [ 10 ] Many pharmaceutical companies have attempted to develop orally bioavailable DTI drugs but dabigatran etexilate is the only one to reach the market.
Dabigatran is an oral direct thrombin inhibitor. Dabigatran (Pradaxa) was found to be noninferior to Warfarin in prevention of ischemic stroke, as well as intracranial hemorrhage risk and overall mortality for non-valvular atrial fibrillation according to the RE-LY trial. [9]
It occurs more often in males and older people. [2] About 44% of those affected die within a month. [2] A good outcome occurs in about 20% of those affected. [2] Intracerebral hemorrhage, a type of hemorrhagic stroke, was first distinguished from ischemic strokes due to insufficient blood flow, so called "leaks and plugs", in 1823. [6]
The most common presentation of cerebrovascular disease is an ischemic stroke or mini-stroke and sometimes a hemorrhagic stroke. [2] Hypertension (high blood pressure) is the most important contributing risk factor for stroke and cerebrovascular diseases as it can change the structure of blood vessels and result in atherosclerosis . [ 5 ]
Symptoms that can prompt a trip to the emergency room include severe dehydration and difficulty breathing. In babies, a warning sign is not having a wet diaper for eight to 10 hours straight.
Depending on where the stroke is located in the brain, symptoms may start within minutes, or they make take hours to present themselves. Most strokes occur without warning. Some common symptoms include one sided weakness, facial paralysis or numbness, vision problems, trouble speaking, problems with walking and keeping balanced.
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109 S High St #100, Columbus, OH · Directions · (614) 224-4261